In this study, the researchers selected some male wild mice and randomly divided them into three groups. The first group was fed with conventional food, the second group was fed with high-fat food for a week, which contained more than 60% of energy, and fed the third group with a high-fat diet for three months. In addition, all mice were fed with eggc. The results showed that eggc had no significant effect on the most suitable mice group, but in the high-fat diet group, the overeating habits were improved and the frequency of food intake and eating decreased. EGCG supplementation can avoid excessive diet in daytime high-fat diet (HFD) mice, that is, EGCG can regulate the diet behavior and steady-state energy of mice.

 

In addition, the researchers found that EGCG regulated the appetite management of key genes such as AgRP, POMC and CART expression, and affected the circadian clock genes in the hypothalamus of obese mice. EGCG was given to mice.